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Hemoglobin, zeta
Protein HBZ PDB 1jeb.png
PDB rendering based on 1jeb.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HBZ ; HBZ-T1; HBZ1
External IDs OMIM142310 MGI96019 HomoloGene110705 GeneCards: HBZ Gene
RNA expression pattern
PBB GE HBZ 206647 at tn.png
PBB GE HBZ gnf1h08166 at tn.png
PBB GE HBZ gnf1h08167 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3050 15126
Ensembl ENSG00000130656 ENSMUSG00000055609
UniProt P02008 P06467
RefSeq (mRNA) NM_005332 NM_010405
RefSeq (protein) NP_005323 NP_034535
Location (UCSC) Chr 16:
0.15 – 0.15 Mb
Chr 11:
32.28 – 32.28 Mb
PubMed search [1] [2]

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.[1][2]

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.[2]


  1. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. PMID 2649166. 
  2. ^ a b "Entrez Gene: HBZ hemoglobin, zeta". 

Further reading[edit]