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Histone deacetylase 10
Symbols HDAC10 ; HD10
External IDs OMIM608544 MGI2158340 HomoloGene23749 IUPHAR: 2614 ChEMBL: 5103 GeneCards: HDAC10 Gene
EC number
Species Human Mouse
Entrez 83933 170787
Ensembl ENSG00000100429 ENSMUSG00000062906
UniProt Q969S8 Q6P3E7
RefSeq (mRNA) NM_001159286 NM_199198
RefSeq (protein) NP_001152758 NP_954668
Location (UCSC) Chr 22:
50.68 – 50.69 Mb
Chr 15:
89.12 – 89.13 Mb
PubMed search [1] [2]

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.[1][2][3]

Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM][3]


HDAC10 has been shown to interact with Histone deacetylase 2[4] and Nuclear receptor co-repressor 2.[4]

See also[edit]


  1. ^ Kao HY, Lee CH, Komarov A, Han CC, Evans RM (Jan 2002). "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase". J Biol Chem 277 (1): 187–93. doi:10.1074/jbc.M108931200. PMID 11677242. 
  2. ^ Guardiola AR, Yao TP (Jan 2002). "Molecular cloning and characterization of a novel histone deacetylase HDAC10". J Biol Chem 277 (5): 3350–6. doi:10.1074/jbc.M109861200. PMID 11726666. 
  3. ^ a b "Entrez Gene: HDAC10 histone deacetylase 10". 
  4. ^ a b Fischer, Denise D; Cai Richard; Bhatia Umesh; Asselbergs Fred A M; Song Chuanzheng; Terry Robert; Trogani Nancy; Widmer Roland; Atadja Peter; Cohen Dalia (Feb 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. (United States) 277 (8): 6656–66. doi:10.1074/jbc.M108055200. ISSN 0021-9258. PMID 11739383. 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.