HDAC10

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HDAC10
Identifiers
AliasesHDAC10, HD10, histone deacetylase 10
External IDsMGI: 2158340 HomoloGene: 23749 GeneCards: HDAC10
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for HDAC10
Genomic location for HDAC10
Band22q13.33Start50,245,183 bp[1]
End50,251,405 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032019
NM_001159286

NM_199198

RefSeq (protein)

NP_001152758
NP_114408

NP_954668

Location (UCSC)Chr 22: 50.25 – 50.25 MbChr 15: 89.12 – 89.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.[5][6][7]

Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM][7]

Interactions[edit]

HDAC10 has been shown to interact with Histone deacetylase 2[8] and Nuclear receptor co-repressor 2.[8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100429 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062906 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kao HY, Lee CH, Komarov A, Han CC, Evans RM (Jan 2002). "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase". J Biol Chem. 277 (1): 187–93. doi:10.1074/jbc.M108931200. PMID 11677242.
  6. ^ Guardiola AR, Yao TP (Jan 2002). "Molecular cloning and characterization of a novel histone deacetylase HDAC10". J Biol Chem. 277 (5): 3350–6. doi:10.1074/jbc.M109861200. PMID 11726666.
  7. ^ a b "Entrez Gene: HDAC10 histone deacetylase 10".
  8. ^ a b Fischer, Denise D; Cai Richard; Bhatia Umesh; Asselbergs Fred A M; Song Chuanzheng; Terry Robert; Trogani Nancy; Widmer Roland; Atadja Peter; Cohen Dalia (Feb 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. United States. 277 (8): 6656–66. doi:10.1074/jbc.M108055200. ISSN 0021-9258. PMID 11739383.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.