Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromatin structure and affects transcription. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains that appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Retracts the Cilium of the cell, which is necessary prior to mitosis of the cell.
HDAC also encourages cell motility and catalyzes α-tubulindeacetylation. as a result the enzyme also encourages cancer cell metastasis.
HDAC6 also affects transcription and translation by regulating the heat-shock protein 90 (Hsp90) and stress granules (SGs), respectively.
HDAC6 is also known to bond with high affinity to ubiquitinated proteins. HDAC6 is also required in the formation of SG (Stress granule proteins and is instrumental in SG formation; pharmacological inhibition or genetic removal of HDAC6 abolished SG formation.
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