HEPPS (buffer)

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IUPAC name
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
Other names
3D model (JSmol)
ECHA InfoCard 100.036.528 Edit this at Wikidata
Molar mass 252.33 g·mol−1
Melting point (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.[1]

Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.[2][3][4] HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.[5][6][7]

See also[edit]


  1. ^ Good, N. E; Winget, G. D; Winter, W; Connolly, T. N; Izawa, S; Singh, R. M (1966). "Hydrogen ion buffers for biological research". Biochemistry. 5 (2): 467–77. doi:10.1021/bi00866a011. PMID 5942950.
  2. ^ "Small Molecule Breaks Up Amyloid Aggregates In Mice". Chemical & Engineering News. Retrieved 14 December 2015.
  3. ^ Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. doi:10.1038/ncomms9997. PMC 4686862. PMID 26646366.
  4. ^ "Chemical clears Alzheimer's protein and restores memory in mice". MedicalXpress. Retrieved December 10, 2015.
  5. ^ Kim, YoungSoo; Yoo, Yong Kyoung; Kim, Hye Yun; Roh, Jee Hoon; Kim, Jinsik; Baek, Seungyeop; Lee, Jinny Claire; Kim, Hye Jin; Chae, Myung-Sic; Jeong, Dahye; Park, Dongsung (2019-04-01). "Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system". Science Advances. 5 (4): eaav1388. doi:10.1126/sciadv.aav1388. ISSN 2375-2548.
  6. ^ "Blood Test for Detecting Pre-symptomatic Alzheimer's Disease is Refined". Analysis & Separations from Technology Networks. Retrieved 2019-09-30.
  7. ^ "A possible blood test for early-stage Alzheimer's disease". medicalxpress.com. Retrieved 2019-09-30.