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Hes family bHLH transcription factor 6
Symbols HES6 ; C-HAIRY1; HES-6; bHLHb41; bHLHc23
External IDs OMIM610331 MGI1859852 HomoloGene23111 GeneCards: HES6 Gene
RNA expression pattern
PBB GE HES6 gnf1h00306 at tn.png
More reference expression data
Species Human Mouse
Entrez 55502 55927
Ensembl ENSG00000144485 ENSMUSG00000067071
UniProt Q96HZ4 Q9JHE6
RefSeq (mRNA) NM_001142853 NM_019479
RefSeq (protein) NP_001136325 NP_062352
Location (UCSC) Chr 2:
238.24 – 238.24 Mb
Chr 1:
91.41 – 91.41 Mb
PubMed search [1] [2]

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.[1][2]


HES6 has been shown to interact with TLE1.[3]


  1. ^ Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development 127 (13): 2933–43. PMID 10851137. 
  2. ^ "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)". 
  3. ^ Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.