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Hes-related family bHLH transcription factor with YRPW motif 1
Protein HEY1 PDB 2db7.png
PDB rendering based on 2db7.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HEY1 ; BHLHb31; CHF2; HERP2; HESR1; HRT-1; OAF1; hHRT1
External IDs OMIM602953 MGI1341800 HomoloGene7756 GeneCards: HEY1 Gene
RNA expression pattern
PBB GE HEY1 44783 s at tn.png
PBB GE HEY1 218839 at tn.png
More reference expression data
Species Human Mouse
Entrez 23462 15213
Ensembl ENSG00000164683 ENSMUSG00000040289
UniProt Q9Y5J3 Q9QUM5
RefSeq (mRNA) NM_001040708 NM_010423
RefSeq (protein) NP_001035798 NP_034553
Location (UCSC) Chr 8:
79.76 – 79.77 Mb
Chr 3:
8.66 – 8.67 Mb
PubMed search [1] [2]

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.[1][2][3]

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.[3]


  1. ^ Leimeister C, Externbrink A, Klamt B, Gessler M (Sep 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech Dev 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358. 
  2. ^ Kokubo H, Lun Y, Johnson RL (Aug 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochem Biophys Res Commun 260 (2): 459–65. doi:10.1006/bbrc.1999.0880. PMID 10403790. 
  3. ^ a b "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.