HEY1

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HEY1
Protein HEY1 PDB 2db7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1, hes related family bHLH transcription factor with YRPW motif 1
External IDs MGI: 1341800 HomoloGene: 7756 GeneCards: 23462
RNA expression pattern
PBB GE HEY1 218839 at tn.png

PBB GE HEY1 44783 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012258
NM_001040708
NM_001282851

NM_010423

RefSeq (protein)

NP_001035798.1
NP_001269780.1
NP_036390.3

n/a

Location (UCSC) Chr 8: 79.76 – 79.77 Mb Chr 3: 8.66 – 8.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.[1][2][3]

Function[edit]

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.[3]

References[edit]

  1. ^ Leimeister C, Externbrink A, Klamt B, Gessler M (Jul 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mechanisms of Development 85 (1-2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358. 
  2. ^ Kokubo H, Lun Y, Johnson RL (Jul 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochemical and Biophysical Research Communications 260 (2): 459–65. doi:10.1006/bbrc.1999.0880. PMID 10403790. 
  3. ^ a b "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.