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HFC may stand for:
- Hafnium carbide (HfC)
- Hydrofluorocarbons (HFC), organic compounds that contain only hydrogen, fluorine, and carbon atoms
- 3-(heptafluoropropyl-hydroxymethylene)-d-camphorate, a ligand used in the chiral shift reagent Eu(hfc)3
- HFC Bank, part of HSBC Finance
- Home Finance Company, known in Ghana as "HFC Bank"
- Hourly (Price) Forward Curve, a tool to estimate the development of (commodity) prices, e.g. based on current whole-sale electricity stock exchange prices.
- Hall for Cornwall, a theatre in Cornwall, UK.
- Heng Fa Chuen, a town located on the Eastern part of Hong Kong Island, Hong Kong
- Heng Fa Chuen Station, Hong Kong; MTR Station Code HFC (located within Heng Fa Chuen)
- Hallescher FC, a German soccer club
- Haughmond F.C., an English semi-professional football club
- Hawthorn Football Club, an Australian rules football club
- Heart of Midlothian F.C. ("Hearts"), a Scottish association football club
- Heidelberg Football Club, an Australian rules football club
- Hendon F.C., an English Football club
- Hereford F.C., an English Football club
- Hibernian F.C., a Scottish association football club
- Histon F.C., an English association football club
- Horsham F.C., an English Football club
- Hull FC, a British rugby league football club
- Hyde FC, English Football club
- Koninklijke HFC, a Dutch football club
- Home Front Command, a military term used in a military-civilian population context
- High Field Consultants, a company specializing in phenomena that occur in high electric fields
- High frequency content measure, simple measure, taken across a signal spectrum
- Hundred Flowers Campaign, brief interlude in the People's Republic of China from 1956 to 1957
- Hybrid fiber-coaxial, a telecommunications industry term for a type of broadband network
- House Freedom Caucus, a conservative Republican caucus in the U.S. House of Representatives, founded in 2015
- Hydrogen Fuel Cell, a type of vehicle power plant when compressed hydrogen is delivered from a tank, turned into water by mixing it with air, which produces energy to a battery, and drives an electric motor.
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