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HGF activator
Protein HGFAC PDB 1ybw.png
PDB rendering based on 1ybw.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HGFAC ; HGFA
External IDs OMIM604552 MGI1859281 HomoloGene1170 GeneCards: HGFAC Gene
EC number 3.4.21.-
RNA expression pattern
PBB GE HGFAC 207027 at tn.png
More reference expression data
Species Human Mouse
Entrez 3083 54426
Ensembl ENSG00000109758 ENSMUSG00000029102
UniProt Q04756 Q9R098
RefSeq (mRNA) NM_001297439 NM_019447
RefSeq (protein) NP_001284368 NP_062320
Location (UCSC) Chr 4:
3.44 – 3.45 Mb
Chr 5:
35.04 – 35.05 Mb
PubMed search [1] [2]

Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.[1][2][3]

The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.[3]


  1. ^ Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N (Jun 1993). "Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor. Structural similarity of the protease precursor to blood coagulation factor XII". J Biol Chem 268 (14): 10024–8. PMID 7683665. 
  2. ^ Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N (Dec 1993). "Activation of the zymogen of hepatocyte growth factor activator by thrombin". J Biol Chem 268 (30): 22927–32. PMID 8226803. 
  3. ^ a b "Entrez Gene: HGFAC HGF activator". 

Further reading[edit]