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Protein HIP2 PDB 1yla.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases UBE2K, E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin conjugating enzyme E2 K
External IDs MGI: 1858216 HomoloGene: 3903 GeneCards: UBE2K
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for UBE2K
Genomic location for UBE2K
Band 4p14 Start 39,698,044 bp[1]
End 39,782,792 bp[1]
RNA expression pattern
PBB GE HIP2 202347 s at fs.png

PBB GE HIP2 202346 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 4: 39.7 – 39.78 Mb Chr 5: 65.54 – 65.6 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.[5][6][7]

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.[7]


HIP2 has been shown to interact with Huntingtin[5][8] and RNF2.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078140 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029203 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR (Sep 1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J Biol Chem. 271 (32): 19385–94. doi:10.1074/jbc.271.32.19385. PMID 8702625. 
  6. ^ Christensen DE, Brzovic PS, Klevit RE (Oct 2007). "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages". Nat Struct Mol Biol. 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885. 
  7. ^ a b "Entrez Gene: HIP2 huntingtin interacting protein 2". 
  8. ^ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202. 
  9. ^ Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (Aug 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855. 

Further reading[edit]