HIP2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
UBE2K
Protein HIP2 PDB 1yla.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UBE2K, E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin conjugating enzyme E2 K
External IDs MGI: 1858216 HomoloGene: 3903 GeneCards: UBE2K
RNA expression pattern
PBB GE HIP2 202347 s at fs.png

PBB GE HIP2 202346 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016786
NM_001310618
NM_001310619

RefSeq (protein)

NP_058066.2
NP_001297547
NP_001297548
NP_058066

Location (UCSC) Chr 4: 39.7 – 39.78 Mb Chr 5: 65.54 – 65.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.[3][4][5]

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.[5]

Interactions[edit]

HIP2 has been shown to interact with Huntingtin[3][6] and RNF2.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR (Sep 1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J Biol Chem. 271 (32): 19385–94. doi:10.1074/jbc.271.32.19385. PMID 8702625. 
  4. ^ Christensen DE, Brzovic PS, Klevit RE (Oct 2007). "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages". Nat Struct Mol Biol. 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885. 
  5. ^ a b "Entrez Gene: HIP2 huntingtin interacting protein 2". 
  6. ^ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202. 
  7. ^ Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (Aug 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855. 

Further reading[edit]