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AliasesHIST1H1D, H1.3, H1D, H1F3, H1s-2, histone cluster 1, H1d, histone cluster 1 H1 family member d
External IDsMGI: 107502 HomoloGene: 68456 GeneCards: HIST1H1D
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HIST1H1D
Genomic location for HIST1H1D
Band6p22.2Start26,234,268 bp[1]
End26,234,933 bp[1]
RNA expression pattern
PBB GE HIST1H1D 214537 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 26.23 – 26.23 MbChr 13: 23.55 – 23.56 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Histone H1.3 is a protein that in humans is encoded by the HIST1H1D gene.[5][6][7]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124575 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052565 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
  6. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. ^ a b "Entrez Gene: HIST1H1D histone cluster 1, H1d".

Further reading[edit]