HIST1H1E

From Wikipedia, the free encyclopedia
Jump to: navigation, search
HIST1H1E
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases HIST1H1E, histone cluster 1, H1e, H1.4, H1E, H1F4, H1s-4, dJ221C16.5
External IDs HomoloGene: 130534 GeneCards: HIST1H1E
RNA expression pattern
PBB GE HIST1H1E 222067 x at fs.png

PBB GE HIST1H1E 208553 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005321

n/a

RefSeq (protein)

NP_005312
NP_005312.1

n/a

Location (UCSC) Chr 6: 26.16 – 26.16 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Histone H1.4 is a protein that in humans is encoded by the HIST1H1E gene.[2][3][4]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H1E histone cluster 1, H1e". 

Further reading[edit]