HIST1H2AA

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HIST1H2AA
Protein HIST1H2AA PDB 1aoi.png
Identifiers
Aliases HIST1H2AA, H2AA, H2AFR, bA317E16.2, TH2A, histone cluster 1, H2aa
External IDs MGI: 2448297 HomoloGene: 108269 GeneCards: HIST1H2AA
RNA expression pattern
PBB GE HIST1H2AA gnf1h05799 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170745

NM_178183

RefSeq (protein)

NP_734466

NP_835490.1
NP_835490

Location (UCSC) Chr 6: 25.73 – 25.73 Mb Chr 13: 21.75 – 21.75 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2A type 1-A is a protein that in humans is encoded by the HIST1H2AA gene.[3][4]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H2AA histone cluster 1, H2aa". 

Further reading[edit]