HIST1H2AC

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HIST1H2AC
Protein HIST1H2AC PDB 1aoi.png
Identifiers
Aliases HIST1H2AC, H2A/l, H2AFL, dJ221C16.4, histone cluster 1, H2ac
External IDs MGI: 2448302 HomoloGene: 130459 GeneCards: HIST1H2AC
RNA expression pattern
PBB GE HIST1H2AC 215071 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003512

NM_001177544

RefSeq (protein)

NP_003503

Location (UCSC) Chr 6: 26.12 – 26.14 Mb Chr 13: 21.81 – 21.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2A type 1-C is a protein that in humans is encoded by the HIST1H2AC gene.[3][4][5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  4. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  5. ^ a b "Entrez Gene: HIST1H2AC histone cluster 1, H2ac". 

Further reading[edit]