HIST1H2AI

From Wikipedia, the free encyclopedia
Jump to: navigation, search
HIST1H2AI
Protein HIST1H2AI PDB 1aoi.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases HIST1H2AI, H2A/c, H2AFC, histone cluster 1, H2ai, histone cluster 1 H2A family member i
External IDs HomoloGene: 134476 GeneCards: HIST1H2AI
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HIST1H2AI
Genomic location for HIST1H2AI
Band 6p22.1 Start 27,808,199 bp[1]
End 27,808,701 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003509

n/a

RefSeq (protein)

NP_003501
NP_066408
NP_003500
NP_003505
NP_003502

n/a

Location (UCSC) Chr 6: 27.81 – 27.81 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AI gene.[3][4][5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196747 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  4. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  5. ^ a b "Entrez Gene: HIST1H2AI histone cluster 1, H2ai". 

Further reading[edit]