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Histone cluster 1, H2al
Protein HIST1H2AL PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H2AL ; H2A.i; H2A/i; H2AFI; dJ193B12.9
External IDs OMIM602793 MGI3646032 HomoloGene136768 GeneCards: HIST1H2AL Gene
Species Human Mouse
Entrez 8332 319166
Ensembl ENSG00000276903 ENSMUSG00000069272
UniProt P0C0S8 P22752
RefSeq (mRNA) NM_003511 NM_178187
RefSeq (protein) NP_003502 NP_835494
Location (UCSC) Chr 6:
27.87 – 27.87 Mb
Chr 13:
23.57 – 23.57 Mb
PubMed search [1] [2]

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AL gene.[1][2][3][4]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[4]


  1. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  2. ^ Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H2AL histone cluster 1, H2al". 

Further reading[edit]