HIST1H2AM

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HIST1H2AM
Protein HIST1H2AM PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HIST1H2AM, H2A.1, H2A/n, H2AFN, dJ193B12.1, histone cluster 1, H2am
External IDs MGI: 2448289 HomoloGene: 136769 GeneCards: 8336
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003514

NM_178188

RefSeq (protein)

NP_003500.1
NP_003501.1
NP_003502.1
NP_003505.1
NP_066408.1

Location (UCSC) Chr 6: 27.89 – 27.89 Mb Chr 13: 23.57 – 23.57 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AM gene.[1][2][3][4]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[4]

References[edit]

  1. ^ Dobner T, Wolf I, Mai B, Lipp M (Feb 1992). "A novel divergently transcribed human histone H2A/H2B gene pair". DNA Seq 1 (6): 409–13. doi:10.3109/10425179109020799. PMID 1768865. 
  2. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H2AM histone cluster 1, H2am". 

Further reading[edit]