HIST1H2BA

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HIST1H2BA
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HIST1H2BA, H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3, TH2B, histone cluster 1, H2ba
External IDs MGI: 2448375 HomoloGene: 69356 GeneCards: HIST1H2BA
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170610

NM_175663

RefSeq (protein)

NP_733759

NP_783594.1
NP_783594

Location (UCSC) Chr 6: 25.73 – 25.73 Mb Chr 13: 23.93 – 23.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene.[3][4][5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ Zalensky AO, Siino JS, Gineitis AA, Zalenskaya IA, Tomilin NV, Yau P, Bradbury EM (Nov 2002). "Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization". J Biol Chem. 277 (45): 43474–80. doi:10.1074/jbc.M206065200. PMID 12213818. 
  5. ^ a b "Entrez Gene: HIST1H2BA histone cluster 1, H2ba". 

Further reading[edit]