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Protein HIST1H2BB PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases HIST1H2BB, H2B.1, H2B/f, H2BFF, histone cluster 1, H2bb
External IDs MGI: 2448377 HomoloGene: 137348 GeneCards: HIST1H2BB
RNA expression pattern
PBB GE HIST1H2BB 208547 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 26.04 – 26.04 Mb Chr 13: 23.75 – 23.75 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Histone H2B type 1-B is a protein that in humans is encoded by the HIST1H2BB gene.[3][4][5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kardalinou E, Eick S, Albig W, Doenecke D (Dec 1993). "Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones". J Cell Biochem. 52 (4): 375–83. doi:10.1002/jcb.240520402. PMID 8227173. 
  4. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  5. ^ a b "Entrez Gene: HIST1H2BB histone cluster 1, H2bb". 

Further reading[edit]