HIST1H2BD

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HIST1H2BD
Protein HIST1H2BD PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HIST1H2BD, H2B.1B, H2B/b, H2BFB, HIRIP2, dJ221C16.6, histone cluster 1, H2bd
External IDs MGI: 1925553 HomoloGene: 134740 GeneCards: HIST1H2BD
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021063
NM_138720

NM_030082

RefSeq (protein)

NP_084358.1
NP_084358

Location (UCSC) Chr 6: 26.16 – 26.17 Mb Chr 11: 58.95 – 58.95 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2B type 1-D is a protein that in humans is encoded by the HIST1H2BD gene.[3][4][5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryote. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825. 
  4. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  5. ^ a b "Entrez Gene: HIST1H2BD histone cluster 1, H2bd". 

Further reading[edit]