HIST1H2BJ

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HIST1H2BJ
Protein HIST1H2BJ PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HIST1H2BJ, H2B/r, H2BFR, H2BJ, histone cluster 1, H2bj, histone cluster 1 H2B family member j
External IDs MGI: 2448415 HomoloGene: 128594 GeneCards: HIST1H2BJ
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HIST1H2BJ
Genomic location for HIST1H2BJ
Band 6p22.1 Start 27,125,897 bp[1]
End 27,132,750 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021058

NM_178214

RefSeq (protein)

NP_066402

NP_835586

Location (UCSC) Chr 6: 27.13 – 27.13 Mb Chr 3: 96.22 – 96.22 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2B type 1-J is a protein that in humans is encoded by the HIST1H2BJ gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124635 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068854 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Zhong R, Roeder RG, Heintz N (Jan 1984). "The primary structure and expression of four cloned human histone genes". Nucleic Acids Res. 11 (21): 7409–7425. doi:10.1093/nar/11.21.7409. PMC 326492Freely accessible. PMID 6647026. 
  6. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  7. ^ a b "Entrez Gene: HIST1H2BJ histone cluster 1, H2bj". 

Further reading[edit]