HIST1H2BK

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HIST1H2BK
Protein HIST1H2BK PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HIST1H2BK, H2B/S, H2BFAiii, H2BFT, H2BK, histone cluster 1, H2bk
External IDs MGI: 2448399 HomoloGene: 135980 GeneCards: HIST1H2BK
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080593
NM_001312653

NM_175665

RefSeq (protein)

NP_001299582
NP_542160

NP_783596.1
NP_783596

Location (UCSC) Chr 6: 27.15 – 27.15 Mb Chr 13: 22.04 – 22.04 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.[3][4]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.[4]

Interactions[edit]

HIST1H2BK has been shown to interact with HIRA.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H2BK histone cluster 1, H2bk". 
  5. ^ Lorain, S; Quivy J P; Monier-Gavelle F; Scamps C; Lécluse Y; Almouzni G; Lipinski M (Sep 1998). "Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA". Mol. Cell. Biol. UNITED STATES. 18 (9): 5546–56. ISSN 0270-7306. PMC 109139Freely accessible. PMID 9710638. 

Further reading[edit]