From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Protein HIST1H2BK PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases HIST1H2BK, H2B/S, H2BFAiii, H2BFT, H2BK, histone cluster 1, H2bk, histone cluster 1 H2B family member k
External IDs MGI: 2448399 HomoloGene: 135980 GeneCards: HIST1H2BK
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HIST1H2BK
Genomic location for HIST1H2BK
Band 6p22.1 Start 27,146,418 bp[1]
End 27,146,798 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 27.15 – 27.15 Mb Chr 13: 22.04 – 22.04 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.[5][6]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.[6]


HIST1H2BK has been shown to interact with HIRA.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197903 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062727 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  6. ^ a b "Entrez Gene: HIST1H2BK histone cluster 1, H2bk". 
  7. ^ Lorain, S; Quivy J P; Monier-Gavelle F; Scamps C; Lécluse Y; Almouzni G; Lipinski M (Sep 1998). "Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA". Mol. Cell. Biol. UNITED STATES. 18 (9): 5546–56. ISSN 0270-7306. PMC 109139Freely accessible. PMID 9710638. 

Further reading[edit]