HIST1H2BL

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H2BC13
Protein HIST1H2BL PDB 1aoi.png
Identifiers
AliasesH2BC13, H2B/c, H2BFC, dJ97D16.4, histone cluster 1, H2bl, histone cluster 1 H2B family member l, H2B clustered histone 13, HIST1H2BL
External IDsOMIM: 602800 MGI: 2448388 HomoloGene: 136771 GeneCards: H2BC13
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for H2BC13
Genomic location for H2BC13
Band6p22.1Start27,807,444 bp[1]
End27,807,931 bp[1]
RNA expression pattern
PBB GE HIST1H2BK 208579 x at fs.png

PBB GE HIST1H2BL 208527 x at fs.png

PBB GE HIST1H2BL 207611 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003519

NM_178198

RefSeq (protein)

NP_003510

NP_001091448
NP_001300809
NP_835502
NP_835505

Location (UCSC)Chr 6: 27.81 – 27.81 MbChr 13: 22.04 – 22.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2B type 1-L is a protein that in humans is encoded by the HIST1H2BL gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185130 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069300 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
  6. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. ^ a b "Entrez Gene: HIST1H2BL histone cluster 1, H2bl".

Further reading[edit]