HIST1H2BO

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HIST1H2BO
Protein HIST1H2BO PDB 1aoi.png
Identifiers
Aliases HIST1H2BO, H2B.2, H2B/n, H2BFN, dJ193B12.2, histone cluster 1, H2bo
External IDs MGI: 2448409 HomoloGene: 134442 GeneCards: HIST1H2BO
RNA expression pattern
PBB GE HIST1H2BO 214540 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003527

NM_001290466
NM_178202

RefSeq (protein)

NP_003518

NP_001277395.1
NP_835509.2
NP_001277395
NP_835509

Location (UCSC) Chr 6: 27.89 – 27.89 Mb Chr 13: 21.79 – 21.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2B type 1-O is a protein that in humans is encoded by the HIST1H2BO gene.[3][4][5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Dobner T, Wolf I, Mai B, Lipp M (Feb 1992). "A novel divergently transcribed human histone H2A/H2B gene pair". DNA Seq. 1 (6): 409–13. doi:10.3109/10425179109020799. PMID 1768865. 
  4. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  5. ^ a b "Entrez Gene: HIST1H2BO histone cluster 1, H2bo". 

Further reading[edit]