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Protein HIST1H3B PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases HIST1H3B, H3/l, H3FL, histone cluster 1, H3b, histone cluster 1 H3 family member b
External IDs MGI: 2448351 HomoloGene: 136775 GeneCards: HIST1H3B
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HIST1H3B
Genomic location for HIST1H3B
Band 6p22.2 Start 26,031,650 bp[1]
End 26,032,060 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)
Location (UCSC) Chr 6: 26.03 – 26.03 Mb Chr 3: 96.27 – 96.27 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Histone H3.1 is a protein that in humans is encoded by the HIST1H3B gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000274267 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074403 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Zhong R, Roeder RG, Heintz N (Jan 1984). "The primary structure and expression of four cloned human histone genes". Nucleic Acids Res. 11 (21): 7409–25. doi:10.1093/nar/11.21.7409. PMC 326492Freely accessible. PMID 6647026. 
  6. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  7. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  8. ^ "Entrez Gene: HIST1H3B histone cluster 1, H3b". 

Further reading[edit]