HIST1H3F

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HIST1H3F
Protein HIST1H3F PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HIST1H3F, H3/i, H3FI, histone cluster 1, H3f, histone cluster 1 H3 family member f
External IDs MGI: 2448350 HomoloGene: 134472 GeneCards: HIST1H3F
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HIST1H3F
Genomic location for HIST1H3F
Band 6p22.2 Start 26,250,195 bp[1]
End 26,250,605 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021018

NM_178207

RefSeq (protein)

NP_835513

Location (UCSC) Chr 6: 26.25 – 26.25 Mb Chr 13: 21.78 – 21.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone H3.1 is a protein that in humans is encoded by the HIST1H3F gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000277775 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000101972 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  6. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  7. ^ a b "Entrez Gene: HIST1H3F histone cluster 1, H3f". 

Further reading[edit]