From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Protein HIST1H4B PDB 1aoi.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesH4C2, H4/I, H4FI, histone cluster 1, H4b, histone cluster 1 H4 family member b, H4 clustered histone 2, HIST1H4B, H4C5, H4C4, H4C9, H4C12, H4-16, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6
External IDsOMIM: 602829 MGI: 2448443 HomoloGene: 134493 GeneCards: H4C2
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for H4C2
Genomic location for H4C2
Band6p22.2Start26,026,815 bp[1]
End26,027,252 bp[1]
RefSeq (mRNA)



RefSeq (protein)
Location (UCSC)Chr 6: 26.03 – 26.03 MbChr 6: 136.8 – 136.8 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Histone H4 is a protein that in humans is encoded by the HIST1H4B gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 147 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000278705 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096010 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–322. doi:10.1006/geno.1996.4592. PMID 9119399.
  6. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. ^ a b "Entrez Gene: HIST1H4B histone cluster 1, H4b".

Further reading[edit]