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Histone cluster 1, H4e
Protein HIST1H4E PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H4E ; H4/j; H4FJ
External IDs OMIM602830 HomoloGene134463 GeneCards: HIST1H4E Gene
Species Human Mouse
Entrez 8367 n/a
Ensembl ENSG00000276966 n/a
UniProt P62805 n/a
RefSeq (mRNA) NM_003545 n/a
RefSeq (protein) NP_003536 n/a
Location (UCSC) Chr 6:
26.2 – 26.2 Mb
PubMed search [1] n/a

Histone H4 is a protein that in humans is encoded by the HIST1H4E gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]


  1. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H4E histone cluster 1, H4e". 

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