HIST1H4L

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HIST1H4L
Protein HIST1H4L PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HIST1H4L, H4.k, H4/k, H4FK, histone cluster 1, H4l, histone cluster 1 H4 family member l
External IDs MGI: 4843992 HomoloGene: 136248 GeneCards: HIST1H4L
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HIST1H4L
Genomic location for HIST1H4L
Band 6p22.1 Start 27,873,199 bp[1]
End 27,873,510 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003546

NM_175657

RefSeq (protein)
Location (UCSC) Chr 6: 27.87 – 27.87 Mb Chr 6: 21.83 – 21.83 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone H4 is a protein that in humans is encoded by the HIST1H4L gene.[5][6][7][8]

Function[edit]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000275126 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069305 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620. 
  6. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  7. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  8. ^ a b "Entrez Gene: HIST1H4L histone cluster 1, H4l". 

Further reading[edit]