Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
^Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W (Jun 1994). "The relative expression of human histone H2A genes is similar in different types of proliferating cells". DNA Cell Biol. 13 (2): 161–70. doi:10.1089/dna.1994.13.161. PMID8179821.
^Braastad CD, Hovhannisyan H, van Wijnen AJ, Stein JL, Stein GS (Nov 2004). "Functional characterization of a human histone gene cluster duplication". Gene. 342 (1): 35–40. doi:10.1016/j.gene.2004.07.036. PMID15527963.
Allen BS, Stein JL, Stein GS, Ostrer H (1991). "Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6.". Genomics. 10 (2): 486–8. doi:10.1016/0888-7543(91)90337-E. PMID2071153.
Kaiser P, Mandl S, Schweiger M, Schneider R (1996). "Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2.". FEBS Lett. 377 (2): 193–6. doi:10.1016/0014-5793(95)01323-7. PMID8543049.
Wang ZF, Tisovec R, Debry RW, et al. (1997). "Characterization of the 55-kb mouse histone gene cluster on chromosome 3.". Genome Res. 6 (8): 702–14. doi:10.1101/gr.6.8.702. PMID8858345.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID11080476.