HIST2H2AA3

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HIST2H2AA3
Protein HIST2H2AA3 PDB 1aoi.png
Identifiers
Aliases HIST2H2AA3, H2A, H2A.2, H2A/O, H2A/q, H2AFO, H2a-615, HIST2H2AA, histone cluster 2, H2aa3
External IDs MGI: 96097 HomoloGene: 116071 GeneCards: HIST2H2AA3
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003516

NM_013549

RefSeq (protein)

NP_003507
NP_001035807

NP_038577.1
NP_835584.1
NP_835584
NP_038577

Location (UCSC) Chr 1: 149.84 – 149.84 Mb Chr 3: 96.25 – 96.25 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2A type 2-A is a protein that in humans is encoded by the HIST2H2AA3 gene.[3][4][5][6]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Marashi F, Prokopp K, Stein J, Stein G (May 1984). "Evidence for a human histone gene cluster containing H2B and H2A pseudogenes". Proc Natl Acad Sci U S A. 81 (7): 1936–40. doi:10.1073/pnas.81.7.1936. PMC 345411Freely accessible. PMID 6326092. 
  4. ^ Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W (Jun 1994). "The relative expression of human histone H2A genes is similar in different types of proliferating cells". DNA Cell Biol. 13 (2): 161–70. doi:10.1089/dna.1994.13.161. PMID 8179821. 
  5. ^ Braastad CD, Hovhannisyan H, van Wijnen AJ, Stein JL, Stein GS (Nov 2004). "Functional characterization of a human histone gene cluster duplication". Gene. 342 (1): 35–40. doi:10.1016/j.gene.2004.07.036. PMID 15527963. 
  6. ^ a b "Entrez Gene: HIST2H2AA3 histone cluster 2, H2aa3". 

Further reading[edit]