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Protein HIST2H2AC PDB 1aoi.png
Aliases HIST2H2AC, H2A, H2A-GL101, H2A/q, H2AFQ, histone cluster 2, H2ac
External IDs MGI: 2448316 HomoloGene: 128596 GeneCards: HIST2H2AC
RNA expression pattern
PBB GE HIST2H2AC 218280 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 149.89 – 149.89 Mb Chr 3: 96.22 – 96.22 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Histone H2A type 2-C is a protein that in humans is encoded by the HIST2H2AC gene.[3][4][5][6]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Collart D, Romain PL, Huebner K, Pockwinse S, Pilapil S, Cannizzaro LA, Lian JB, Croce CM, Stein JL, Stein GS (Jan 1993). "A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing". J Cell Biochem. 50 (4): 374–85. doi:10.1002/jcb.240500406. PMID 1469070. 
  4. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  5. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  6. ^ a b "Entrez Gene: HIST2H2AC histone cluster 2, H2ac". 

Further reading[edit]