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Protein HIST2H4A PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases HIST2H4A, FO108, H4, H4/n, H4F2, H4FN, HIST2H4, histone cluster 2, H4a, histone cluster 2 H4 family member a
External IDs MGI: 2448420 HomoloGene: 134466 GeneCards: HIST2H4A
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)
Location (UCSC) Chr 1: 149.83 – 149.84 Mb Chr 13: 23.76 – 23.76 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Histone H4 is a protein that in humans is encoded by the HIST2H4A gene.[3][4][5][6]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Pauli U, Chrysogelos S, Stein G, Stein J, Nick H (Jul 1987). "Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene". Science. 236 (4806): 1308–11. doi:10.1126/science.3035717. PMID 3035717. 
  4. ^ Sierra F, Stein G, Stein J (Dec 1983). "Structure and in vitro transcription of a human H4 histone gene". Nucleic Acids Res. 11 (20): 7069–86. doi:10.1093/nar/11.20.7069. PMC 326439Freely accessible. PMID 6314274. 
  5. ^ Braastad CD, Hovhannisyan H, van Wijnen AJ, Stein JL, Stein GS (Nov 2004). "Functional characterization of a human histone gene cluster duplication". Gene. 342 (1): 35–40. doi:10.1016/j.gene.2004.07.036. PMID 15527963. 
  6. ^ a b "Entrez Gene: HIST2H4A histone cluster 2, H4a". 

Further reading[edit]