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Protein HIST3H3 PDB 1aoi.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases HIST3H3, H3.4, H3/g, H3FT, H3t, histone cluster 3, H3
External IDs HomoloGene: 133212 GeneCards: HIST3H3
RNA expression pattern
PBB GE HIST3H3 208572 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 228.42 – 228.43 Mb n/a
PubMed search [1] n/a
View/Edit Human

Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene.[2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.[4]


  1. ^ "Human PubMed Reference:". 
  2. ^ Albig W, Ebentheuer J, Klobeck G, Kunz J, Doenecke D (Dec 1996). "A solitary human H3 histone gene on chromosome 1". Hum Genet. 97 (4): 486–91. doi:10.1007/BF02267072. PMID 8834248. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ "Entrez Gene: HIST3H3 histone cluster 3, H3". 

Further reading[edit]