From Wikipedia, the free encyclopedia
Jump to: navigation, search
Human immunodeficiency virus type I enhancer binding protein 3
Symbols HIVEP3 ; KBP-1; KBP1; KRC; SHN3; Schnurri-3; ZAS3; ZNF40C
External IDs OMIM606649 MGI106589 HomoloGene7803 GeneCards: HIVEP3 Gene
RNA expression pattern
PBB GE HIVEP3 220042 x at tn.png
More reference expression data
Species Human Mouse
Entrez 59269 16656
Ensembl ENSG00000127124 ENSMUSG00000028634
UniProt Q5T1R4 A2A884
RefSeq (mRNA) NM_001127714 NM_010657
RefSeq (protein) NP_001121186 NP_034787
Location (UCSC) Chr 1:
41.51 – 42.04 Mb
Chr 4:
119.73 – 120.14 Mb
PubMed search [1] [2]

Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.[1][2]


Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][2]


HIVEP3 has been shown to interact with TRAF1[3] and TRAF2.[3]


  1. ^ Hicar MD, Liu Y, Allen CE, Wu LC (Jan 2001). "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2". Genomics 71 (1): 89–100. doi:10.1006/geno.2000.6425. PMID 11161801. 
  2. ^ a b "Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3". 
  3. ^ a b Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (Jan 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Molecular Cell 9 (1): 121–31. doi:10.1016/S1097-2765(01)00434-8. PMID 11804591. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.