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major histocompatibility complex, class II, DO alpha
Symbol HLA-DOA
Alt. symbols HLA-DZA, HLA-DNA
Entrez 3111
HUGO 4936
OMIM 142930
RefSeq NM_002119
UniProt Q9TQD3
Other data
Locus Chr. 6 p21.3
major histocompatibility complex, class II, DO beta
Symbol HLA-DOB
Entrez 3112
HUGO 4937
OMIM 600629
RefSeq NM_002120
UniProt P13765
Other data
Locus Chr. 6 p21.3

HLA-DO is a dimeric Major Histocompatibility Complex (MHC) Class II protein composed of α- and β-subunits which interacts with HLA-DM in order to fine tune immunodominant epitope selection.[1][2] As elucidated by studies performed on its mouse-analog, H2-O, the polymorphic and evolutionarily conserved features of HLA-DO indicate that evolutionary benefits may be conferred to the host by this molecule.[3]





  1. ^ Fallas JL, Tobin HM, Lou O, Guo D, Sant'Angelo DB, Denzin LK (August 2004). "Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation". J. Immunol. 173 (3): 1549–60. doi:10.4049/jimmunol.173.3.1549. PMID 15265882. 
  2. ^ Sadegh-Nasseri S (2016). "A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cells". F1000Research. 5. doi:10.12688/f1000research.7664.1. PMC 4902097Freely accessible. PMID 27347387. 
  3. ^ Poluektov YO, Kim A, Sadegh-Nasseri S (August 2013). "HLA-DO and Its Role in MHC Class II Antigen Presentation". Frontiers in Immunology. 4: 260. doi:10.3389/fimmu.2013.00260. PMC 3756479Freely accessible. PMID 24009612.