HLA-DOA

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HLA-DOA
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases HLA-DOA, HLA-DNA, HLA-DZA, HLADZ, HLA-DOA, major histocompatibility complex, class II, DO alpha
External IDs MGI: 95924 HomoloGene: 1601 GeneCards: 3111
Genetically Related Diseases
Disease Name References
periodontitis
RNA expression pattern
PBB GE HLA-DOA 206313 at tn.png

PBB GE HLA-DOA 211142 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002119

NM_008206

RefSeq (protein)

NP_002110.1

n/a

Location (UCSC) Chr 6: 33 – 33.01 Mb Chr 17: 34.09 – 34.1 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.[4][5]

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.[5]

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_824&geneId=66461". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Young JA, Trowsdale J (Aug 1990). "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript". Immunogenetics. 31 (5–6): 386–8. doi:10.1007/BF02115015. PMID 2370084. 
  5. ^ a b "Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha". 

Further reading[edit]