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Major histocompatibility complex, class I, F
Symbols HLA-F ; CDA12; HLA-5.4; HLA-CDA12; HLAF
External IDs OMIM143110 MGI95931 HomoloGene133121 GeneCards: HLA-F Gene
RNA expression pattern
PBB GE HLA-F 204806 x at tn.png
PBB GE HLA-F 221875 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3134 630294
Ensembl ENSG00000137403 ENSMUSG00000092243
UniProt P30511 A7VMS3
RefSeq (mRNA) NM_001098478 NM_001177467
RefSeq (protein) NP_001091948 NP_001170938
Location (UCSC) Chr 6:
29.72 – 29.74 Mb
Chr 17:
36.11 – 36.13 Mb
PubMed search [1] [2]

HLA class I histocompatibility antigen, alpha chain F is a protein that in humans is encoded by the HLA-F gene.[1][2]

HLA-F belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-F binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 42 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. The HLA-F gene exhibits few polymorphisms.[2]


Further reading[edit]