HLF (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Hepatic leukemia factor
Symbols HLF ; MGC33822
External IDs OMIM142385 MGI96108 HomoloGene31074 GeneCards: HLF Gene
RNA expression pattern
PBB GE HLF 204753 s at tn.png
PBB GE HLF 204754 at tn.png
PBB GE HLF 204755 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3131 217082
Ensembl ENSG00000108924 ENSMUSG00000003949
UniProt Q16534 Q8BW74
RefSeq (mRNA) NM_002126 NM_172563
RefSeq (protein) NP_002117 NP_766151
Location (UCSC) Chr 17:
55.27 – 55.33 Mb
Chr 11:
90.34 – 90.39 Mb
PubMed search [1] [2]

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[1][2]

This monster gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[2]


  1. ^ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (Aug 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science 257 (5069): 531–4. doi:10.1126/science.1386162. PMID 1386162. 
  2. ^ a b "Entrez Gene: HLF hepatic leukemia factor". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.