HMG-CoA

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HMG-CoA
HMG coenzyme A.svg
Names
IUPAC name
(9R,21S)-1-[(2R,3S,4R,5R)-5-

(6-amino-9H-purin-9-yl)-4-hydroxy- 3-(phosphonooxy)tetrahydrofuran-2-yl]- 3,5,9,21-tetrahydroxy-8,8,21-trimethyl- 10,14,19-trioxo-2,4,6-trioxa-18-thia- 11,15-diaza-3,5-diphosphatricosan-23-

oic acid 3,5-dioxide
Identifiers
1553-55-5 YesY
ChEBI CHEBI:61659 YesY
ChemSpider 392859 YesY
3040
Jmol 3D model Interactive image
MeSH HMG-CoA
PubChem 445127
Properties
C27H44N7O20P3S
Molar mass 911.661 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

HMG-CoA (or 3-hydroxy-3-methylglutaryl-coenzyme A) is an intermediate in the mevalonate and ketogenesis pathways. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase. The researches of Minor J. Coon and Bimal Kumar Bachhawat in the 1950s at University of Illinois led to its discovery.[1][2]

It is also an intermediate in the metabolism of leucine. Its immediate precursor is 3-methylglutaconyl CoA.

Mevalonate pathway[edit]

Main article: Mevalonate pathway

HMG-CoA reductase converts it into mevalonic acid.

Mevalonate pathway

Ketogenesis pathway[edit]

HMG-CoA lyase breaks it into acetyl CoA and acetoacetate.

References[edit]

  1. ^ Debi P. Sarkar (2015). "Classics in Indian Medicine" (PDF). The National Medical Journal of India (28): 3. 
  2. ^ Avadhesha Surolia (1997). "An outstanding scientist and a splendid human being" (PDF). Glycobiology. 7 (4): v–ix.