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High mobility group nucleosome binding domain 1
Symbols HMGN1 ; HMG14
External IDs OMIM163920 MGI96120 HomoloGene3643 GeneCards: HMGN1 Gene
Species Human Mouse
Entrez 3150 15312
Ensembl ENSG00000205581 ENSMUSG00000040681
UniProt P05114 P18608
RefSeq (mRNA) NM_004965 NM_008251
RefSeq (protein) NP_004956 NP_032277
Location (UCSC) Chr 21:
39.34 – 39.35 Mb
Chr 16:
96.12 – 96.13 Mb
PubMed search [1] [2]

Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.[1][2][3]


Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM][3]


HMGN1 has been shown to interact with YWHAZ.[4]


  1. ^ Landsman D, Srikantha T, Westermann R, Bustin M (Dec 1986). "Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family". The Journal of Biological Chemistry 261 (34): 16082–6. PMID 3782107. 
  2. ^ Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M (Feb 1989). "Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family". The Journal of Biological Chemistry 264 (6): 3421–7. PMID 2563381. 
  3. ^ a b "Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1". 
  4. ^ Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins". Molecular and Cellular Biology 22 (19): 6809–19. doi:10.1128/MCB.22.19.6809-6819.2002. PMC 134047. PMID 12215538. 

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