HMGN1

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HMGN1
Identifiers
Aliases HMGN1, HMG14, high mobility group nucleosome binding domain 1
External IDs MGI: 96120 HomoloGene: 3643 GeneCards: HMGN1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004965

NM_008251

RefSeq (protein)

NP_004956

NP_032277.3
NP_032277

Location (UCSC) Chr 21: 39.34 – 39.35 Mb Chr 16: 96.12 – 96.13 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.[3][4][5]

Function[edit]

Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation.[6] Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[5]

Interactions[edit]

HMGN1 has been shown to interact with YWHAZ.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Landsman D, Srikantha T, Westermann R, Bustin M (Dec 1986). "Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family". The Journal of Biological Chemistry. 261 (34): 16082–6. PMID 3782107. 
  4. ^ Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M (Feb 1989). "Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family". The Journal of Biological Chemistry. 264 (6): 3421–7. PMID 2563381. 
  5. ^ a b "Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1". 
  6. ^ Martínez de Paz A, Ausió J (2016). "HMGNs: The enhancer charmers". BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 38 (3): 226–31. doi:10.1002/bies.201500157. PMID 26709929. 
  7. ^ Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins". Molecular and Cellular Biology. 22 (19): 6809–19. doi:10.1128/MCB.22.19.6809-6819.2002. PMC 134047Freely accessible. PMID 12215538. 

Further reading[edit]