From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aliases HMGN3, PNAS-25, TRIP7, PNAS-24, high mobility group nucleosomal binding domain 3
External IDs HomoloGene: 130417 GeneCards: 9324
RNA expression pattern
PBB GE HMGN3 209377 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 6: 79.2 – 79.23 Mb n/a
PubMed search [1] n/a
View/Edit Human

High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene.[2][3][4]

Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene.[4]


  1. ^ "Human PubMed Reference:". 
  2. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974. 
  3. ^ West KL, Ito Y, Birger Y, Postnikov Y, Shirakawa H, Bustin M (Jul 2001). "HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome-binding proteins". J Biol Chem. 276 (28): 25959–69. doi:10.1074/jbc.M101692200. PMID 11356838. 
  4. ^ a b "Entrez Gene: HMGN3 high mobility group nucleosomal binding domain 3". 

Further reading[edit]

External links[edit]