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High mobility group nucleosomal binding domain 3
Symbols HMGN3 ; PNAS-24; PNAS-25; TRIP7
External IDs OMIM604502 MGI2138069 HomoloGene130417 GeneCards: HMGN3 Gene
RNA expression pattern
PBB GE HMGN3 209377 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9324 94353
Ensembl ENSG00000118418 ENSMUSG00000066456
UniProt Q15651 Q9DCB1
RefSeq (mRNA) NM_001201362 NM_026122.4
RefSeq (protein) NP_001188291 NP_080398.1
Location (UCSC) Chr 6:
79.2 – 79.23 Mb
Chr 9:
83 – 83.04 Mb
PubMed search [1] [2]

High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene.[1][2][3]

Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene.[3]


  1. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974. 
  2. ^ West KL, Ito Y, Birger Y, Postnikov Y, Shirakawa H, Bustin M (Jul 2001). "HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome-binding proteins". J Biol Chem 276 (28): 25959–69. doi:10.1074/jbc.M101692200. PMID 11356838. 
  3. ^ a b "Entrez Gene: HMGN3 high mobility group nucleosomal binding domain 3". 

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