HMOX1

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HMOX1
Protein HMOX1 PDB 1n3u.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HMOX1, HMOX1D, HO-1, HSP32, bK286B10, heme oxygenase 1
External IDs OMIM: 141250 MGI: 96163 HomoloGene: 31075 GeneCards: 3162
Genetically Related Diseases
Disease Name References
obesity
RNA expression pattern
PBB GE HMOX1 203665 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002133

NM_010442

RefSeq (protein)

NP_002124.1

NP_034572.1

Location (UCSC) Chr 22: 35.38 – 35.39 Mb Chr 8: 75.09 – 75.1 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

HMOX1 (heme oxygenase (decycling) 1) is a human gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). Heme oxygenase mediates the first step of heme catabolism, it cleaves heme to form biliverdin.

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, carbon monoxide, and ferrous iron.[4] The biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.[5]

The HMOX gene is located on the long (q) arm of chromosome 22 at position 12.3, from base pair 34,101,636 to base pair 34,114,748.

Related conditions[edit]

Heme oxygenase-1 deficiency

Anti-inflammatory effect[edit]

The ability of oxygenase 1 to catabolize free heme and produce carbon monoxide (CO) gives its antiinflammatory properties by up-regulation of interleukin 10 (IL-10) and interleukin 1 receptor antagonist (IL-1RA) expression.[6]

See also[edit]

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_9970&geneId=70857". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Lehninger's Principles of Biochemistry, 5th Edition. New York: W.H. Freeman and Company. 2008. p. 876. ISBN 978-0-7167-7108-1. 
  5. ^ "Entrez Gene: HMOX1 heme oxygenase (decycling) 1". 
  6. ^ Piantadosi CA, Withers CM, Bartz RR, MacGarvey NC, Fu P, Sweeney TE, Welty-Wolf KE, Suliman HB (May 2011). "Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression". J. Biol. Chem. 286 (18): 16374–85. doi:10.1074/jbc.M110.207738. PMC 3091243free to read. PMID 21454555. 

Further reading[edit]