HMOX1

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
HMOX1
Protein HMOX1 PDB 1n3u.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHMOX1, HMOX1D, HO-1, HSP32, bK286B10, heme oxygenase 1
External IDsOMIM: 141250 MGI: 96163 HomoloGene: 31075 GeneCards: HMOX1
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for HMOX1
Genomic location for HMOX1
Band22q12.3Start35,380,361 bp[1]
End35,394,214 bp[1]
RNA expression pattern
PBB GE HMOX1 203665 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002133

NM_010442

RefSeq (protein)

NP_002124

NP_034572

Location (UCSC)Chr 22: 35.38 – 35.39 MbChr 8: 75.09 – 75.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HMOX1 (heme oxygenase (decycling) 1) is a human gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). Heme oxygenase mediates the first step of heme catabolism, it cleaves heme to form biliverdin.

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, carbon monoxide, and ferrous iron.[5] The biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.[6]

The HMOX gene is located on the long (q) arm of chromosome 22 at position 12.3, from base pair 34,101,636 to base pair 34,114,748.

Related conditions[edit]

Anti-inflammatory effect[edit]

The ability of oxygenase 1 to catabolize free heme and produce carbon monoxide (CO) gives its anti-inflammatory properties by up-regulation of interleukin 10 (IL-10) and interleukin 1 receptor antagonist (IL-1RA) expression.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100292 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005413 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lehninger's Principles of Biochemistry, 5th Edition. New York: W.H. Freeman and Company. 2008. p. 876. ISBN 978-0-7167-7108-1. 
  6. ^ "Entrez Gene: HMOX1 heme oxygenase (decycling) 1". 
  7. ^ Piantadosi CA, Withers CM, Bartz RR, MacGarvey NC, Fu P, Sweeney TE, Welty-Wolf KE, Suliman HB (May 2011). "Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression". J. Biol. Chem. 286 (18): 16374–85. doi:10.1074/jbc.M110.207738. PMC 3091243Freely accessible. PMID 21454555. 

Further reading[edit]