HNRNPR

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HNRNPR
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases HNRNPR, HNRPR, hnRNP-R, heterogeneous nuclear ribonucleoprotein R
External IDs MGI: 1891692 HomoloGene: 4251 GeneCards: HNRNPR
RNA expression pattern
PBB GE HNRPR 208765 s at fs.png

PBB GE HNRPR 208766 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001277121
NM_001277122
NM_001277123
NM_028871

RefSeq (protein)

n/a

Location (UCSC) Chr 1: 23.3 – 23.34 Mb Chr 4: 136.31 – 136.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein R is a protein that in humans is encoded by the HNRNPR gene.[3][4]

Function[edit]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization motif.[4]

Interactions[edit]

HNRNPR has been shown to interact with SMN1[5][6] and PRMT1.[7][8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hassfeld W, Chan EK, Mathison DA, Portman D, Dreyfuss G, Steiner G, Tan EM (Jan 1998). "Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P". Nucleic Acids Research. 26 (2): 439–45. doi:10.1093/nar/26.2.439. PMC 147279Freely accessible. PMID 9421497. 
  4. ^ a b "Entrez Gene: HNRPR heterogeneous nuclear ribonucleoprotein R". 
  5. ^ Mourelatos Z, Abel L, Yong J, Kataoka N, Dreyfuss G (Oct 2001). "SMN interacts with a novel family of hnRNP and spliceosomal proteins". The EMBO Journal. 20 (19): 5443–52. doi:10.1093/emboj/20.19.5443. PMC 125643Freely accessible. PMID 11574476. 
  6. ^ Rossoll W, Kröning AK, Ohndorf UM, Steegborn C, Jablonka S, Sendtner M (Jan 2002). "Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?". Human Molecular Genetics. 11 (1): 93–105. doi:10.1093/hmg/11.1.93. PMID 11773003. 
  7. ^ Wada K, Inoue K, Hagiwara M (Aug 2002). "Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy". Biochimica et Biophysica Acta. 1591 (1-3): 1–10. doi:10.1016/S0167-4889(02)00202-1. PMID 12183049. 
  8. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 

Further reading[edit]

External links[edit]