HNRPH1

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HNRNPH1
Protein HNRPH1 PDB 1wez.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HNRNPH1, HNRPH, HNRPH1, hnRNPH, heterogeneous nuclear ribonucleoprotein H1 (H)
External IDs MGI: 1891925 HomoloGene: 31318 GeneCards: HNRNPH1
RNA expression pattern
PBB GE HNRPH1 213470 s at fs.png

PBB GE HNRPH1 201031 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001257293
NM_005520

NM_021510
NM_001347487

RefSeq (protein)

NP_001244222
NP_005511

NP_067485.1
NP_001334416
NP_067485

Location (UCSC) Chr 5: 179.61 – 179.63 Mb Chr 11: 50.38 – 50.39 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein H is a protein that in humans is encoded by the HNRNPH1 gene.[3][4]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. It is very similar to the family member HNRPF. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem. 270 (48): 28780–9. doi:10.1074/jbc.270.48.28780. PMID 7499401. 
  4. ^ a b "Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)". 

Further reading[edit]