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Protein HNRPK PDB 1j5k.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases HNRNPK, CSBP, HNRPK, TUNP, AUKS, heterogeneous nuclear ribonucleoprotein K
External IDs MGI: 99894 HomoloGene: 81909 GeneCards: HNRNPK
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for HNRNPK
Genomic location for HNRNPK
Band 9q21.32 Start 83,968,083 bp[1]
End 83,980,616 bp[1]
RNA expression pattern
PBB GE HNRPK 200775 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 9: 83.97 – 83.98 Mb Chr 9: 58.39 – 58.4 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein K is a protein that in humans is encoded by the HNRNPK gene.[5]


This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Multiple alternatively spliced transcript variants have been described for this gene but only three variants have been fully described.[6]


HNRPK has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165119 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021546 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Dejgaard K, Leffers H, Rasmussen HH, Madsen P, Kruse TA, Gesser B, Nielsen H, Celis JE (March 1994). "Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing". J Mol Biol. 236 (1): 33–48. doi:10.1006/jmbi.1994.1116. PMID 8107114. 
  6. ^ "Entrez Gene: HNRPK heterogeneous nuclear ribonucleoprotein K". 
  7. ^ Ostareck-Lederer A, Ostareck DH, Cans C, Neubauer G, Bomsztyk K, Superti-Furga G, Hentze MW (July 2002). "c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs". Mol. Cell. Biol. 22 (13): 4535–43. doi:10.1128/mcb.22.13.4535-4543.2002. PMC 133888Freely accessible. PMID 12052863. 
  8. ^ Chen HC, Lin WC, Tsay YG, Lee SC, Chang CJ (October 2002). "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K". J. Biol. Chem. 277 (43): 40403–9. doi:10.1074/jbc.M206981200. PMID 12183465. 
  9. ^ a b c Kim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol. 298 (3): 395–405. doi:10.1006/jmbi.2000.3687. PMID 10772858. 
  10. ^ Yang JP, Reddy TR, Truong KT, Suhasini M, Wong-Staal F (October 2002). "Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K". Oncogene. 21 (47): 7187–94. doi:10.1038/sj.onc.1205759. PMID 12370808. 
  11. ^ Côté J, Boisvert FM, Boulanger MC, Bedford MT, Richard S (January 2003). "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1". Mol. Biol. Cell. 14 (1): 274–87. doi:10.1091/mbc.E02-08-0484. PMC 140244Freely accessible. PMID 12529443. 
  12. ^ Wada K, Inoue K, Hagiwara M (August 2002). "Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy". Biochim. Biophys. Acta. 1591 (1-3): 1–10. doi:10.1016/s0167-4889(02)00202-1. PMID 12183049. 

Further reading[edit]