This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Multiple alternatively spliced transcript variants have been described for this gene but only three variants have been fully described.
^Dejgaard K, Leffers H, Rasmussen HH, Madsen P, Kruse TA, Gesser B, Nielsen H, Celis JE (March 1994). "Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing". J Mol Biol236 (1): 33–48. doi:10.1006/jmbi.1994.1116. PMID8107114.
^Chen HC, Lin WC, Tsay YG, Lee SC, Chang CJ (October 2002). "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K". J. Biol. Chem.277 (43): 40403–9. doi:10.1074/jbc.M206981200. PMID12183465.
^ abcKim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol.298 (3): 395–405. doi:10.1006/jmbi.2000.3687. PMID10772858.
^Yang JP, Reddy TR, Truong KT, Suhasini M, Wong-Staal F (October 2002). "Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K". Oncogene21 (47): 7187–94. doi:10.1038/sj.onc.1205759. PMID12370808.
^Wada K, Inoue K, Hagiwara M (August 2002). "Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy". Biochim. Biophys. Acta1591 (1-3): 1–10. doi:10.1016/s0167-4889(02)00202-1. PMID12183049.
Buckanovich RJ, Posner JB, Darnell RB (1993). "Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system". Neuron11 (4): 657–72. doi:10.1016/0896-6273(93)90077-5. PMID8398153.
Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ (1996). "Identification of Itk/Tsk Src homology 3 domain ligands". J. Biol. Chem.271 (41): 25646–56. doi:10.1074/jbc.271.41.25646. PMID8810341.
Tommerup N, Leffers H (1997). "Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A". Genomics32 (2): 297–8. doi:10.1006/geno.1996.0121. PMID8833161.
Miau LH, Chang CJ, Shen BJ, Tsai WH, Lee SC (1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation". J. Biol. Chem.273 (17): 10784–91. doi:10.1074/jbc.273.17.10784. PMID9553145.
Hsieh TY, Matsumoto M, Chou HC, Schneider R, Hwang SB, Lee AS, Lai MM (1998). "Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K". J. Biol. Chem.273 (28): 17651–9. doi:10.1074/jbc.273.28.17651. PMID9651361.
Schullery DS, Ostrowski J, Denisenko ON, Stempka L, Shnyreva M, Suzuki H, Gschwendt M, Bomsztyk K (1999). "Regulated interaction of protein kinase Cdelta with the heterogeneous nuclear ribonucleoprotein K protein". J. Biol. Chem.274 (21): 15101–9. doi:10.1074/jbc.274.21.15101. PMID10329716.
Baber JL, Libutti D, Levens D, Tjandra N (1999). "High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcription factor". J. Mol. Biol.289 (4): 949–62. doi:10.1006/jmbi.1999.2818. PMID10369774.
Wadd S, Bryant H, Filhol O, Scott JE, Hsieh TY, Everett RD, Clements JB (1999). "The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2". J. Biol. Chem.274 (41): 28991–8. doi:10.1074/jbc.274.41.28991. PMID10506147.
Venables JP, Elliott DJ, Makarova OV, Makarov EM, Cooke HJ, Eperon IC (2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Hum. Mol. Genet.9 (5): 685–94. doi:10.1093/hmg/9.5.685. PMID10749975.
Kim JH, Hahm B, Kim YK, Choi M, Jang SK (2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol.298 (3): 395–405. doi:10.1006/jmbi.2000.3687. PMID10772858.
Shnyreva M, Schullery DS, Suzuki H, Higaki Y, Bomsztyk K (2000). "Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein". J. Biol. Chem.275 (20): 15498–503. doi:10.1074/jbc.275.20.15498. PMID10809782.