HOMER2

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HOMER2
Protein HOMER2 PDB 1i7a.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHOMER2, ACPD, CPD, HOMER-2, VESL-2, DFNA68, homer scaffolding protein 2, homer scaffold protein 2
External IDsMGI: 1347354 HomoloGene: 3560 GeneCards: HOMER2
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for HOMER2
Genomic location for HOMER2
Band15q25.2Start82,836,946 bp[1]
End82,986,153 bp[1]
RNA expression pattern
PBB GE HOMER2 217080 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004839
NM_199330
NM_199331
NM_199332

NM_001164086
NM_001164087
NM_011983
NM_177029

RefSeq (protein)

NP_004830
NP_955362

NP_001157558
NP_001157559
NP_036113

Location (UCSC)Chr 15: 82.84 – 82.99 MbChr 7: 81.6 – 81.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.[5][6][7]

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.[7]

Interactions[edit]

HOMER2 has been shown to interact with RYR1.[8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103942 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025813 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Dec 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
  6. ^ Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Dec 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.
  7. ^ a b "Entrez Gene: HOMER2 homer homolog 2 (Drosophila)".
  8. ^ Feng, Wei; Tu Jiancheng; Yang Tianzhong; Vernon Patty Shih; Allen Paul D; Worley Paul F; Pessah Isaac N (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. United States. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. ISSN 0021-9258. PMID 12223488.

Further reading[edit]