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Protein HOMER3 PDB 2P8V.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases HOMER3, HOMER-3, VESL3, homer scaffolding protein 3, homer scaffold protein 3
External IDs MGI: 1347359 HomoloGene: 37972 GeneCards: HOMER3
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for HOMER3
Genomic location for HOMER3
Band 19p13.11 Start 18,929,201 bp[1]
End 18,941,261 bp[1]
RNA expression pattern
PBB GE HOMER3 222222 s at fs.png

PBB GE HOMER3 215489 x at fs.png

PBB GE HOMER3 204647 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC) Chr 19: 18.93 – 18.94 Mb Chr 8: 70.28 – 70.29 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.[5][6][7]


This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.[7]


HOMER3 has been shown to interact with TRPC1[8] and RYR1.[9]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000051128 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003573 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (Feb 2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". Journal of Molecular Biology. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696. 
  6. ^ Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Oct 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. 
  7. ^ a b "Entrez Gene: HOMER3 homer homolog 3 (Drosophila)". 
  8. ^ Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576. 
  9. ^ Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". The Journal of Biological Chemistry. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488. 

Further reading[edit]