HOPX

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
HOPX
Protein HOP PDB 2hi3.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHOPX, CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO, HOP homeobox
External IDsMGI: 1916782 HomoloGene: 15859 GeneCards: HOPX
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for HOPX
Genomic location for HOPX
Band4q12Start56,647,988 bp[1]
End56,681,899 bp[1]
RNA expression pattern
PBB GE HOP 211597 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145459
NM_001145460
NM_032495
NM_139211
NM_139212

NM_001159900
NM_001159901
NM_175606

RefSeq (protein)

NP_001138931
NP_001138932
NP_115884
NP_631957
NP_631958

NP_001153372
NP_001153373
NP_783199

Location (UCSC)Chr 4: 56.65 – 56.68 MbChr 5: 77.09 – 77.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene.[5] It is an important regulator of cardiac development[6] and a marker of hippocampal neural stem cells.[7][8]

Function[edit]

The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development.[6] Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171476 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059325 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: HOP homeodomain-only protein".
  6. ^ a b Chen, Fabian; Kook, Hyun; Milewski, Rita; Gitler, Aaron D.; Lu, Min Min; Li, Jun; Nazarian, Ronniel; Schnepp, Robert; Jen, Kuangyu; Biben, Christine; Runke, Greg; Mackay, Joel P.; Novotny, Jiri; Schwartz, Robert J.; Harvey, Richard P.; Mullins, Mary C.; Epstein, Jonathan A. (September 2002). "Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development". Cell. 110 (6): 713–723. doi:10.1016/S0092-8674(02)00932-7.
  7. ^ Li, Deqiang; Takeda, Norifumi; Jain, Rajan; Manderfield, Lauren J.; Liu, Feiyan; Li, Li; Anderson, Stewart A.; Epstein, Jonathan A. (November 2015). "Hopx distinguishes hippocampal from lateral ventricle neural stem cells". Stem Cell Research. 15 (3): 522–529. doi:10.1016/j.scr.2015.09.015.
  8. ^ Berg, Daniel A.; Su, Yijing; Jimenez-Cyrus, Dennisse; Patel, Aneek; Huang, Nancy; Morizet, David; Lee, Stephanie; Shah, Reeti; Ringeling, Francisca Rojas; Jain, Rajan; Epstein, Jonathan A.; Wu, Qing-Feng; Canzar, Stefan; Ming, Guo-Li; Song, Hongjun; Bond, Allison M. (April 2019). "A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis". Cell. 177 (3): 654–668.e15. doi:10.1016/j.cell.2019.02.010.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.