The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.
Asanoma K, Matsuda T, Kondo H, Kato K, Kishino T, Niikawa N, Wake N, Kato H (January 2003). "NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif". Genomics. 81 (1): 15–25. PMID12573257. doi:10.1016/S0888-7543(02)00011-3.
Chen Y, Petersen S, Pacyna-Gengelbach M, Pietas A, Petersen I (2003). "Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer". Oncology. 64 (4): 450–8. PMID12759545. doi:10.1159/000070306.
Toruner GA, Ulger C, Alkan M, Galante AT, Rinaggio J, Wilk R, Tian B, Soteropoulos P, Hameed MR, Schwalb MN, Dermody JJ (October 2004). "Association between gene expression profile and tumor invasion in oral squamous cell carcinoma". Cancer Genetics and Cytogenetics. 154 (1): 27–35. PMID15381369. doi:10.1016/j.cancergencyto.2004.01.026.
Asanoma K, Kato H, Inoue T, Matsuda T, Wake N (August 2004). "Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts". The Journal of Reproductive Medicine. 49 (8): 617–26. PMID15457851.
Kook H, Yung WW, Simpson RJ, Kee HJ, Shin S, Lowry JA, Loughlin FE, Yin Z, Epstein JA, Mackay JP (September 2006). "Analysis of the structure and function of the transcriptional coregulator HOP". Biochemistry. 45 (35): 10584–90. PMID16939210. doi:10.1021/bi060641s.
Kee HJ, Kim JR, Nam KI, Park HY, Shin S, Kim JC, Shimono Y, Takahashi M, Jeong MH, Kim N, Kim KK, Kook H (March 2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". The Journal of Biological Chemistry. 282 (10): 7700–9. PMID17192267. doi:10.1074/jbc.M611198200.
Americo TA, Chiarini LB, Linden R (June 2007). "Signaling induced by hop/STI-1 depends on endocytosis". Biochemical and Biophysical Research Communications. 358 (2): 620–5. PMID17498662. doi:10.1016/j.bbrc.2007.04.202.