HOXA11

From Wikipedia, the free encyclopedia
Jump to: navigation, search
HOXA11
Identifiers
Aliases HOXA11, HOX1, HOX1I, RUSAT1, homeobox A11
External IDs MGI: 96172 HomoloGene: 4033 GeneCards: 3207
RNA expression pattern
PBB GE HOXA11 208493 at tn.png

PBB GE HOXA11 213823 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005523

NM_010450

RefSeq (protein)

NP_005514.1

NP_034580.1

Location (UCSC) Chr 7: 27.18 – 27.19 Mb Chr 6: 52.24 – 52.25 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.[3][4][5]

Function[edit]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  4. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  5. ^ a b "Entrez Gene: HOXA11 homeobox A11". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.