HOXA3

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HOXA3
Identifiers
Aliases HOXA3, HOX1, HOX1E, homeobox A3
External IDs MGI: 96175 HomoloGene: 40725 GeneCards: 3200
RNA expression pattern
PBB GE HOXA3 208604 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030661
NM_153631
NM_153632

NM_010452

RefSeq (protein)

NP_109377.1
NP_705895.1

NP_034582.1

Location (UCSC) Chr 7: 27.11 – 27.15 Mb Chr 6: 52.17 – 52.21 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.[1][2][3]

Function[edit]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.[3]

Regulation[edit]

The HOXA3 gene is repressed by the microRNA miR-10a.[4]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXA3 homeobox A3". 
  4. ^ Han L, Witmer PD, Casey E, Valle D, Sukumar S (August 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy 6 (8): 1284–8. PMID 17660710. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.