HOXA7

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HOXA7
Protein HOXA7 PDB 1ahd.png
Identifiers
Aliases HOXA7, ANTP, HOX1, HOX1.1, HOX1A, homeobox A7
External IDs MGI: 96179 HomoloGene: 56001 GeneCards: 3204
RNA expression pattern
PBB GE HOXA7 206847 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006896

NM_010455

RefSeq (protein)

NP_008827.2

NP_034585.1

Location (UCSC) Chr 7: 27.15 – 27.16 Mb Chr 6: 52.21 – 52.22 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.[3][4][5]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  4. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  5. ^ a b "Entrez Gene: HOXA7 homeobox A7". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.